TY - JOUR
T1 - Controlled Release of Polypeptides and Other Macromolecules
AU - Siegel, Ronald A.
AU - Langer, Robert
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1984/1
Y1 - 1984/1
N2 - The use of polymeric matrices for the controlled release of polypeptides and other macromolecular drugs is reviewed. Three principal mechanisms of release include diffusion of the polypeptide through the polymer, erosion of the polymer matrix, and the application of magnetic fields to force more drug out of the matrix. The diffusion controlled systems generally utilize ethylene-vinyl acetate copolymer. The advantage of these systems is facile manipulation of the pore structure to obtain desired release kinetics. Release of many different polypeptides from these systems for periods of months has been demonstrated. Bioerosion provides the advantage that the polymer system does not need to be retrieved. Magnetism provides a mechanism whereby desired increases and decreases in polypeptide release rates can be achieved on demand.
AB - The use of polymeric matrices for the controlled release of polypeptides and other macromolecular drugs is reviewed. Three principal mechanisms of release include diffusion of the polypeptide through the polymer, erosion of the polymer matrix, and the application of magnetic fields to force more drug out of the matrix. The diffusion controlled systems generally utilize ethylene-vinyl acetate copolymer. The advantage of these systems is facile manipulation of the pore structure to obtain desired release kinetics. Release of many different polypeptides from these systems for periods of months has been demonstrated. Bioerosion provides the advantage that the polymer system does not need to be retrieved. Magnetism provides a mechanism whereby desired increases and decreases in polypeptide release rates can be achieved on demand.
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U2 - 10.1023/A:1016318423563
DO - 10.1023/A:1016318423563
M3 - Review article
AN - SCOPUS:0021241808
SN - 0724-8741
VL - 1
SP - 2
EP - 10
JO - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
JF - Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
IS - 1
ER -