Abstract
The development of injectable microspheres for sustained drug delivery to the arterial wall is a major challenge. We demonstrated the possibility of entrapping an antiproliferative agent, taxol, in poly(ethylene glycol) (PEG)coated biodegradable poly(lactic acid) (PLA) microspheres with a mean diameter of 2-6 μm. A solution of taxol and PLA dissolved in an acetone/dichloromethane mixture was poured into an aqueous solution of PEG [or poly(vinyl alcohol) (PVA] with stirring with a high-speed homogenizer for the formation of microspheres. Taxol recovery in PLA-PEG microspheres was higher (61.2 ± 2.3%) than with PVA-based (41.6 ± 1.8%) preparations. An analysis by diffuse reflectance infrared Fourier transform spectroscopy revealed that PEG was incorporated well on the PLA microsphere surface. Scanning electron microscopy revealed that the PEG-coated PLA microspheres were spherical in shape and had a smooth surface texture like those of PVA-based preparations. The amount of drug release was much higher initially (25-30%); this was followed by a constant slow-release profile for a 30-day period of study. This PEG-coated PLA microsphere formulation may have potential for the targeted delivery of antiproliferative agents to treat restenosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 96-103 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 27 2001 |
Keywords
- Drug delivery
- Microspheres
- Poly(ethylene glycol)
- Poly(lactic acid)
- Taxol