Control of the yeast cell cycle with a photocleavable α-factor analogue

Laurie L. Parker, Josh W. Kurutz, Stephen B.H. Kent, Stephen J. Kron

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Under arrest: Photodegradation of a synthetic yeast α-factor analogue releases yeast from mating-factor-induced arrest into the cell cycle. This peptide has sufficient activity to arrest cells in G1 at reasonable doses and it can be specifically degraded through exposure to UV light at a wavelength that is "safe" for most cells. FITC-A = absorption of a fluorescein isothiocyanate analogue. (Graph Presented).

Original languageEnglish (US)
Pages (from-to)6322-6325
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number38
DOIs
StatePublished - Sep 25 2006

Keywords

  • Biotechnology
  • Peptides
  • Peptidomimetics
  • Pheromones
  • Receptors

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