Control of lipids at baseline in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial

Georgia Pambianco, Manuel Lombardero, Vera Bittner, Alan Forker, Frank Kennedy, Ashok Krishnaswami, Arshag D. Mooradian, Rodica Pop-Busui, Jamal S. Rana, Annabelle Rodriguez, Michael Steffes, Trevor J. Orchard

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Abstract

In order to examine lipids, a major treatment parameter in those with diabetes and heart disease, the authors analyzed baseline data from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. The study consisted of 2368 participants with type 2 diabetes and coronary artery disease from 49 sites in 6 countries (2295 provided lipid measurements). Fifty-nine percent of participants had a low-density lipoprotein (LDL) cholesterol level <100 mg/dL. Levels of total, LDL, and non-high-density lipoprotein (HDL) cholesterol and triglycerides differed by age group (younger than 55, 55-64, and 65 years and older); they were lowest in those aged 65 years. Women had higher total, LDL, and non-HDL cholesterol values. Education was associated with lower total, LDL, and non-HDL cholesterol levels. LDL cholesterol and triglyceride values were lower in the United States and Canada. Adjustment for age, sex, education level, randomization year, and medication did not eliminate these differences. Geographic variation was seen and was not fully accounted for by demographic or treatment characteristics (all P values <.05).

Original languageEnglish (US)
Pages (from-to)9-18
Number of pages10
JournalPreventive cardiology
Volume12
Issue number1
DOIs
StatePublished - Nov 23 2009

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LDL Lipoproteins
Angioplasty
Lipids
LDL Cholesterol
Sex Education
Random Allocation
Type 2 Diabetes Mellitus
Canada
Coronary Artery Disease
Heart Diseases
Age Groups
Demography
Education
Therapeutics
lipoprotein cholesterol

Cite this

Pambianco, G., Lombardero, M., Bittner, V., Forker, A., Kennedy, F., Krishnaswami, A., ... Orchard, T. J. (2009). Control of lipids at baseline in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial. Preventive cardiology, 12(1), 9-18. https://doi.org/10.1111/j.1751-7141.2008.00014.x

Control of lipids at baseline in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial. / Pambianco, Georgia; Lombardero, Manuel; Bittner, Vera; Forker, Alan; Kennedy, Frank; Krishnaswami, Ashok; Mooradian, Arshag D.; Pop-Busui, Rodica; Rana, Jamal S.; Rodriguez, Annabelle; Steffes, Michael; Orchard, Trevor J.

In: Preventive cardiology, Vol. 12, No. 1, 23.11.2009, p. 9-18.

Research output: Contribution to journalArticle

Pambianco, G, Lombardero, M, Bittner, V, Forker, A, Kennedy, F, Krishnaswami, A, Mooradian, AD, Pop-Busui, R, Rana, JS, Rodriguez, A, Steffes, M & Orchard, TJ 2009, 'Control of lipids at baseline in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial', Preventive cardiology, vol. 12, no. 1, pp. 9-18. https://doi.org/10.1111/j.1751-7141.2008.00014.x
Pambianco, Georgia ; Lombardero, Manuel ; Bittner, Vera ; Forker, Alan ; Kennedy, Frank ; Krishnaswami, Ashok ; Mooradian, Arshag D. ; Pop-Busui, Rodica ; Rana, Jamal S. ; Rodriguez, Annabelle ; Steffes, Michael ; Orchard, Trevor J. / Control of lipids at baseline in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) trial. In: Preventive cardiology. 2009 ; Vol. 12, No. 1. pp. 9-18.
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