Control of extracellular potassium levels by retinal glial cell K + siphoning

Eric A. Newman, Donald A. Frambach, Louis L. Odette

Research output: Contribution to journalArticle

371 Scopus citations

Abstract

Efflux of K+ from dissociated salamander Müller cells was measured with ion-selective microelectrodes. When the distal end of an isolated cell was exposed to high concentrations of extracellular K+, efflux occurred primarily from the endfoot, a cell process previously shown to contain most of the K+ conductance of the cell membrane. Computer simulations of K+ dynamics in the retina indicate that shunting ions through the Müller cell endfoot process is more effective in clearing local increases in extracellular K+ from the retina than is diffusion through extracellular space.

Original languageEnglish (US)
Pages (from-to)1174-1175
Number of pages2
JournalScience
Volume225
Issue number4667
DOIs
StatePublished - Jan 1 1984

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