It is of great importance for the cell to precisely coordinate the doubling of the interphase centrosome with nuclear events during the cell cycle and limit the number of centrosomes it contains at the onset of mitosis to two and only two. The penalties for mistakes are abnormal spindle assembly, inappropriate chromosome distribution, and consequently, genomic instability. We review the functional properties of the mechanisms that control when the centrosome duplicates in the cell cycle and the controls for centrosome copy number. We look to limits that are intrinsic to the centrosome itself and controls imposed by cell cycle linked changes in cytoplasmic conditions. Control of centrosome reproduction is exercised at both levels. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
Bibliographical noteFunding Information:
We would like to thank Rick Miller, Betty Thompson, Jim Maller and Conly Rieder for their substantial contributions to many of the studies reviewed here. We especially appreciate the tireless efforts of Rick Miller in preparing the figures for this article. This work was supported by grants to GS from the NIH (GM 30758), the Cabot Family Charitable Trust, and the Trustees of the Worcester Foundation. EH Hinchcliffe is supported by a Cell Biology of Development Post-Doctoral Training Grant (NIH HD07312).
- Cell cycle
- Cell division
- Cyclin dependent duplication