Contributions of natural killer cells to the immune response against Plasmodium

Kristina S. Burrack, Geoffrey T. Hart, Sara E. Hamilton

Research output: Contribution to journalReview article

Abstract

Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection-prior to the activation and expansion of antigen-specific T cells-through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γchain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens.

Original languageEnglish (US)
Article number321
JournalMalaria Journal
Volume18
Issue number1
DOIs
StatePublished - Sep 18 2019

Fingerprint

Plasmodium
Natural Killer Cells
Malaria
Parasites
Plasmodium malariae
Cytokines
Cerebral Malaria
Natural Killer T-Cells
Fc Receptors
Antibodies
Myeloid Cells
Interleukin-10
Vaccination
Lymphocytes
Pathology
T-Lymphocytes
Antigens

Keywords

  • Cytokines
  • Cytotoxicity
  • Malaria
  • NK cells

Cite this

Contributions of natural killer cells to the immune response against Plasmodium. / Burrack, Kristina S.; Hart, Geoffrey T.; Hamilton, Sara E.

In: Malaria Journal, Vol. 18, No. 1, 321, 18.09.2019.

Research output: Contribution to journalReview article

@article{ba75868c37d04a25b222c6eef28a8b78,
title = "Contributions of natural killer cells to the immune response against Plasmodium",
abstract = "Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection-prior to the activation and expansion of antigen-specific T cells-through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γchain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens.",
keywords = "Cytokines, Cytotoxicity, Malaria, NK cells",
author = "Burrack, {Kristina S.} and Hart, {Geoffrey T.} and Hamilton, {Sara E.}",
year = "2019",
month = "9",
day = "18",
doi = "10.1186/s12936-019-2953-1",
language = "English (US)",
volume = "18",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Contributions of natural killer cells to the immune response against Plasmodium

AU - Burrack, Kristina S.

AU - Hart, Geoffrey T.

AU - Hamilton, Sara E.

PY - 2019/9/18

Y1 - 2019/9/18

N2 - Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection-prior to the activation and expansion of antigen-specific T cells-through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γchain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens.

AB - Natural killer (NK) cells are important innate effector cells that are well described in their ability to kill virally-infected cells and tumors. However, there is increasing appreciation for the role of NK cells in the control of other pathogens, including intracellular parasites such as Plasmodium, the cause of malaria. NK cells may be beneficial during the early phase of Plasmodium infection-prior to the activation and expansion of antigen-specific T cells-through cooperation with myeloid cells to produce inflammatory cytokines like IFNγ. Recent work has defined how Plasmodium can activate NK cells to respond with natural cytotoxicity, and inhibit the growth of parasites via antibody-dependent cellular cytotoxicity mechanisms (ADCC). A specialized subset of adaptive NK cells that are negative for the Fc receptor γchain have enhanced ADCC function and correlate with protection from malaria. Additionally, production of the regulatory cytokine IL-10 by NK cells prevents overt pathology and death during experimental cerebral malaria. Now that conditional NK cell mouse models have been developed, previous studies need to be reevaluated in the context of what is now known about other immune populations with similarity to NK cells (i.e., NKT cells and type I innate lymphoid cells). This brief review summarizes recent findings which support the potentially beneficial roles of NK cells during Plasmodium infection in mice and humans. Also highlighted are how the actions of NK cells can be explored using new experimental strategies, and the potential to harness NK cell function in vaccination regimens.

KW - Cytokines

KW - Cytotoxicity

KW - Malaria

KW - NK cells

UR - http://www.scopus.com/inward/record.url?scp=85072385818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072385818&partnerID=8YFLogxK

U2 - 10.1186/s12936-019-2953-1

DO - 10.1186/s12936-019-2953-1

M3 - Review article

C2 - 31533835

AN - SCOPUS:85072385818

VL - 18

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 1

M1 - 321

ER -