Contribution of Tobacco Use and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone to Three Methyl DNA Adducts in Urine

Yi Wang, Sreekanth Narayanapillai, Qi Hu, Naomi Fujioka, Chengguo Xing

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Human urinary DNA adducts may be useful surrogate biomarkers to estimate carcinogen exposure and activation, particularly if such adducts are of high selectivity from a specific carcinogen source. In this report, we provided evidence supporting tobacco use and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) being the dominant source for 3-methyladenine (3-mA), while nontobacco factors contribute significantly to 7-methylguanine and 1-methyladenine in the urine. Upon confirmation in human urine samples from larger populations in the future, urinary 3-mA may be used to estimate NNK bioactivation in smokers and to facilitate the development of a chemopreventive agent against NNK-induced carcinogenesis.

Original languageEnglish (US)
Pages (from-to)836-838
Number of pages3
JournalChemical research in toxicology
Volume31
Issue number9
DOIs
StatePublished - Sep 17 2018

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