Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia

Edith V. Sullivan, Anjali Deshmukh, John E. Desmond, Daniel H. Mathalon, Margaret J. Rosenbloom, Kelvin O. Lim, Adolf Pfefferbaum

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: It is controversial whether cerebellar tissue volume deficits occur in schizophrenia and, if so, what regions and tissue types are affected. Complicating such investigations is the high incidence of alcoholism comorbidity in patients with schizophrenia that itself can contribute to cerebellar abnormalities. Method: We studied 61 healthy men (control subjects), 25 men with alcoholism, 27 men with schizophrenia, and 19 men comorbid for schizophrenia and alcoholism with the use of magnetic resonance imaging. Cerebellar structures were outlined manually, tissue classification was determined statistically, and regional volumes were corrected for normal variation in head size and age. Results: Patients with schizophrenia alone had enlarged fourth ventricles (1.5 SD relative to controls) but showed no cerebellar tissue volume deficits. The alcoholic group had gray and white matter vermian deficits (-0.5 SD), most prominent in anterior superior lobules, and gray matter hemisphere deficits (-0.8 SD), but not fourth ventricle enlargement. The comorbid group had cerebellar hemisphere (-1.3 SD) and vermian gray matter volume deficits (-0.7 SD) and fourth ventricular enlargement (1.6 SD); these abnormalities were greater than in either single-diagnosis group, despite significantly lower levels of alcohol consumption compared with the alcoholic group. Gray matter volume in the anterior superior vermis correlated with lifetime alcohol consumption in the schizophrenic and comorbid groups when combined. Conclusions: Cerebellar tissue volume deficits were detected in schizophrenia only when accompanied by alcoholism. By contrast, fourth ventricular enlargement occurred in schizophrenia even without alcoholism, although it was exacerbated by alcoholism. These findings support a model of cerebellar supersensitivity to alcohol-related tissue volume deficits in schizophrenia.

Original languageEnglish (US)
Pages (from-to)894-902
Number of pages9
JournalArchives of General Psychiatry
Volume57
Issue number9
DOIs
StatePublished - Jan 1 2000

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Alcoholism
Schizophrenia
Fourth Ventricle
Alcohol Drinking
Alcohol
Abuse
Comorbidity
Head
Alcohols
Magnetic Resonance Imaging
Gray Matter
Incidence
Grey Matter
Enlargement

Cite this

Sullivan, E. V., Deshmukh, A., Desmond, J. E., Mathalon, D. H., Rosenbloom, M. J., Lim, K. O., & Pfefferbaum, A. (2000). Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Archives of General Psychiatry, 57(9), 894-902. https://doi.org/10.1001/archpsyc.57.9.894

Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. / Sullivan, Edith V.; Deshmukh, Anjali; Desmond, John E.; Mathalon, Daniel H.; Rosenbloom, Margaret J.; Lim, Kelvin O.; Pfefferbaum, Adolf.

In: Archives of General Psychiatry, Vol. 57, No. 9, 01.01.2000, p. 894-902.

Research output: Contribution to journalArticle

Sullivan, EV, Deshmukh, A, Desmond, JE, Mathalon, DH, Rosenbloom, MJ, Lim, KO & Pfefferbaum, A 2000, 'Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia', Archives of General Psychiatry, vol. 57, no. 9, pp. 894-902. https://doi.org/10.1001/archpsyc.57.9.894
Sullivan, Edith V. ; Deshmukh, Anjali ; Desmond, John E. ; Mathalon, Daniel H. ; Rosenbloom, Margaret J. ; Lim, Kelvin O. ; Pfefferbaum, Adolf. / Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. In: Archives of General Psychiatry. 2000 ; Vol. 57, No. 9. pp. 894-902.
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