Contrast enhancement in cerebral adrenoleukodystrophy: a comparison of T1 TSE and MPRAGE sequences

Research output: Contribution to journalArticlepeer-review


Purpose: To compare conventional T1 TSE with MPRAGE for enhancement detection in cerebral adrenoleukodystrophy (CALD). Materials and methods: Contrast-enhanced T1 TSE and MPRAGE sequences of 34 CALD patients demonstrating enhancement were evaluated. Contrast ratios were calculated by drawing ROIs to the most enhancing part of demyelination and normal-appearing deep white matter on both T1 TSE and MPRAGE. A comparison was performed between ratios using paired T test. Results: Mean age of 34 included male children was 8 (5–11 years). There was no statistically significant difference between T1 TSE and MPRAGE ratios. However, in 4 out of 34 examinations, minimal contrast enhancement was noted only in T1 TSE sequence. Conclusion: Our data indicate that both T1 TSE and MPRAGE sequences are valuable in determining contrast enhancement in CALD. Although there is not a statistically significant difference between the two techniques, T1 TSE sequence appears to be more sensitive for low degree of enhancement.

Original languageEnglish (US)
Pages (from-to)1241-1245
Number of pages5
JournalJapanese Journal of Radiology
Issue number12
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Hakan Cebeci was supported by a grant from The Scientific and Technical Research Council of Turkey (TUBITAK).

Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Japan Radiological Society.


  • Adrenoleukodystrophy
  • Brain
  • Magnetic resonance imaging
  • Sequence

PubMed: MeSH publication types

  • Journal Article


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