Continuous magnetophoretic enrichment of rare tumor cells

D. Nawarathna, P. Kumaresan, Y. Zhang, B. Ferguson, S. H. Oh, K. S. Lam, H. T. Soh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present the Continuous-flow Magnetic Activated Cell Sorter (CMACS) device which is capable of enriching rare magnetic particles with high purity. The microfabricated ferromagnetic strips within the microfluidic channels create high magnetic field gradients, which generate the magnetophoretic separation forces. We report on the effective separation of magnetically labeled Human Lymphoma (Jurkat) cells from non-target cells and compare its performance against commercially available macro-scale systems.

Original languageEnglish (US)
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages122-124
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: Oct 7 2007Oct 11 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period10/7/0710/11/07

Keywords

  • Magnetic separation
  • Rare cell sorting

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  • Cite this

    Nawarathna, D., Kumaresan, P., Zhang, Y., Ferguson, B., Oh, S. H., Lam, K. S., & Soh, H. T. (2007). Continuous magnetophoretic enrichment of rare tumor cells. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 122-124). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.