Continuous infusion of high-dose acyclovir for serious herpesvirus infections

C. V. Fletcher, J. A. Englund, B. Bean, B. Chinnock, D. M. Brundage, Henry H Balfour

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 μmol/liter. Of 12 patients who had continuous infusion for > 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.

Original languageEnglish (US)
Pages (from-to)1375-1378
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number8
StatePublished - 1989


Dive into the research topics of 'Continuous infusion of high-dose acyclovir for serious herpesvirus infections'. Together they form a unique fingerprint.

Cite this