Continuous Glucose Monitoring in Pediatric Diabetic Ketoacidosis

Thomas Pott, Jose Jimenez-Vega, Jessica Parker, Robert Fitzgerald

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Use of real-time continuous glucose monitoring (rtCGM) in ambulatory settings improves overall glycemic control and reduces the incidence of diabetic ketoacidosis (DKA) in adults and children/adolescents with type 1 diabetes (T1D). However, the use of rtCGM in children with DKA has not been well studied. Method: This prospective, single-arm, single-center study assessed the accuracy, reliability, and feasibility of a commercially available rtCGM device compared with point-of-care (POC) capillary and serum glucose values in pediatric patients admitted to the pediatric intensive care unit for DKA. The primary outcome was the accuracy of rtCGM glucose values compared with POC capillary and serum glucose values during standard treatment of DKA as assessed by Clarke Error Grid (CEG) analysis. Secondary outcomes were assessment of the relationship between rtCGM readings and degree of acidosis and mean length of hospital stay (LOS). Results: Data from 35 hospitalized children (mean ± SD age, 11.9 ± 4.1 years) with DKA were included in our analysis. Five hundred twenty-four time-matched glucose values between serum glucose and rtCGM and 91 time-matched glucose values between POC capillary glucose and rtCGM were obtained. The effect of acidosis on accuracy CEG analysis showed 95.4% of the 524 matched CGM/POC pairs and 95.6% of the 91 matched CGM/serum glucose pairs in the clinically acceptable A + B zones. The average LOS was 1.32 ± 0.73 days. Serum bicarbonate level did not appear to affect the accuracy of rtCGM in the setting of DKA. Conclusions: Continuous glucose monitoring use in inpatient pediatric DKA treatment was found to be feasible and reliable.

Original languageEnglish (US)
JournalJournal of Diabetes Science and Technology
DOIs
StateAccepted/In press - 2022

Bibliographical note

Publisher Copyright:
© 2022 Diabetes Technology Society.

Keywords

  • continuous glucose monitoring
  • diabetic ketoacidosis
  • DKA
  • pediatric
  • type 1 diabetes

PubMed: MeSH publication types

  • Journal Article

Fingerprint

Dive into the research topics of 'Continuous Glucose Monitoring in Pediatric Diabetic Ketoacidosis'. Together they form a unique fingerprint.

Cite this