Contemporary management of preterm premature rupture of membranes (PPROM): A survey of maternal-fetal medicine providers

Patrick S. Ramsey, Francis S. Nuthalapaty, George Lu, Susan Ramin, Elizabeth S. Nuthalapaty, Kirk D. Ramin

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73 Scopus citations


This study was undertaken to characterize variations in the management for women with preterm premature rupture of membranes (PPROM) among maternal-fetal medicine (MFM) specialists in the context of current recommendations for clinical practice and evidenced-based practice. We performed a Web-based survey of 1375 MFM providers. Participants were queried on practice characteristics and management issues including use of tocolytics, antibiotics, steroids, and timing of delivery. A total of 508 providers (37%), representing all 50 states and 13 countries, responded to the survey. Only 30% reported a formal departmental protocol for managing women with PPROM. Consistent use of steroids (99.4%) and antibiotics (99.6%) were reported. Administration of steroids was confined to ≤32 weeks by 37%, and ≤34 weeks by 51% of practitioners. Repeated dosing of steroids was uncommon (16%). The antibiotics use and rationale for use varied among respondents. Tocolytics were used by 73% of respondents with magnesium sulfate the main agent used (98%). Use of tocolytics was generally used for 48 hours or less to attain steroid benefit (88%). Amniocentesis was used by 66% of practitioners in the acute evaluation of PPROM. Fetal lung maturity testing was reported by 78% with variability noted with respect to the test used. Outpatient management of women with PPROM after viability was noted by 43% of respondents. Gestational age at which expectant management is abandoned in women with PPROM varied significantly between respondents: ≥34 weeks by 56%, ≥35 weeks by 26%, ≥36 weeks by 12%, and ≥37 weeks by 4.0%. Although many management practices for women with PPROM are consistent with currently available evidence and practice recommendations, substantial variations still exist among MFM providers.

Original languageEnglish (US)
Pages (from-to)1497-1502
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Oct 2004
Externally publishedYes


  • Corticosteroids
  • Expectant management
  • Preterm birth
  • Preterm premature rupture of membranes
  • Survey


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