Constitutively active STAT5 constructs

Lynn M. Heltemes-Harris, Michael A. Farrar

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The transcription factor S ignal T randucer and A ctivator of T ranscription 5 (STAT5) plays an important role in many biological processes. To study STAT5 biology, several different constructs have been designed that render STAT5 constitutively active. These constructs have now been used to generate animal models that allow for targeted expression of constitutively active STAT5 including a model where STAT5 is expressed in developing B and T cells. Herein we brie fly describe the design of constitutively active STAT5 constructs and recent advances in their use.

Original languageEnglish (US)
Title of host publicationJAK-STAT Signalling
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages225-232
Number of pages8
ISBN (Print)9781627032414
DOIs
StatePublished - Jan 1 2013

Publication series

NameMethods in Molecular Biology
Volume967
ISSN (Print)1064-3745

Keywords

  • CD4
  • Constitutively active
  • Phospho flow
  • STAT5
  • Tregs

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