The consistency of the tobacco withdrawal syndrome across repeated periods of abstinence was tested using a modified A-B-A-B design. The large majority of the signs and symptoms of tobacco withdrawal occured during abstinence, returned to baseline, and then recurred during a second abstinence period. This finding suggests that the syndrome is reliable and can be studied with within-subject designs.
Bibliographical noteFunding Information:
The research ias funded by a NIDA research grant (2 ROl DA02988-03), an NHLBI training grant (5T32 HL07328-04), and funds from the State of Minnesota for psychiatric research. The authors thank Kathy Carroll and Alice Luknic for their help.