Conservation and divergence of transcriptional coregulations between box C/D snoRNA and ribosomal protein genes in Ascomycota

Li Ting Diao, Zhen Dong Xiao, Xiao Min Leng, Bin Li, Jun Hao Li, Yu Ping Luo, Si Guang Li, Chuan He Yu, Hui Zhou, Liang Hu Qu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Coordinated assembly of the ribosome is essential for proper translational activity in eukaryotic cells. It is therefore critical to coordinate the expression of components of ribosomal programs with the cell's nutritional status. However, coordinating expression of these components is poorly understood. Here, by combining experimental and computational approaches, we systematically identified box C/D snoRNAs in four fission yeasts and found that the expression of box C/D snoRNA and ribosomal protein (RP) genes were orchestrated by a common Homol-D box, thereby ensuring a constant balance of these two genetic components. Interestingly, such transcriptional coregulations could be observed in most Ascomycota species and were mediated by different cis-regulatory elements. Via the reservation of cis elements, changes in spatial configuration, the substitution of cis elements, and gain or loss of cis elements, the regulatory networks of box C/D snoRNAs evolved to correspond with those of the RP genes, maintaining transcriptional coregulation between box C/D snoRNAs and RP genes. Our results indicate that coregulation via common cis elements is an important mechanism to coordinate expression of the RP and snoRNA genes, which ensures a constant balance of these two components.

Original languageEnglish (US)
Pages (from-to)1376-1385
Number of pages10
JournalRNA
Volume20
Issue number9
DOIs
StatePublished - Sep 2014
Externally publishedYes

Keywords

  • Ascomycota
  • Cis element
  • Ribosomal protein
  • SnoRNA
  • Transcriptional coregulation

Fingerprint

Dive into the research topics of 'Conservation and divergence of transcriptional coregulations between box C/D snoRNA and ribosomal protein genes in Ascomycota'. Together they form a unique fingerprint.

Cite this