Consequences of vascular flow on lung injury induced by mechanical ventilation

Alain F. Broccard, John R. Hotchkiss, Naoto Kuwayama, Douglas A. Olson, Saba Jamal, Douglas O. Wangensteen, John J. Marini

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


To investigate whether the magnitude of blood flow contributes to ventilator-induced lung injury, 14 sets of isolated rabbit lungs were randomized for perfusion at either 300 (Group A: n = 7) or 900 ml/min (Group B: n = 7) while ventilated with 30 cm H2O peak static pressure. Control lungs (Group C: n = 7) were ventilated with lower peak static pressure (15 cm H2O) and perfused at 500 ml/min. Weight gain, changes in the ultrafiltration coefficient (ΔKf) and lung static compliance (CL), and extent of hemorrhage (scored by histology) were compared. Group B had a larger decrease in CL (-13 ± 11%) than Groups A (2 ± 6%) and C (5 ± 5%) (p < 0.05). Group B had more hemorrhage and gained more weight (16.2 ± 9.5 g) than Groups A (8.7 ± 3.4 g) and C (1.6 ± 1.0 g) (p < 0.05 for each pairwise comparison between groups). Finally, Kf (g · min-1 · cm H2O-1 · 100 g-1) increased the most in Group B (ΔKf = 0.26 ± 0.20 versus 0.17 ± 0.10 in Group A and 0.05 ± 0.04 in Group C; p < 0.05 for B versus C). We conclude that the intensity of lung perfusion contributes to ventilator-induced lung injury in this model.

Original languageEnglish (US)
Pages (from-to)1935-1942
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Issue number6 PART I
StatePublished - 1998


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