The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.
Bibliographical noteFunding Information:
Arancillo and Sillitoe: R.V.S is supported by funds from Baylor College of Medicine and Texas Children's Hospital, The Bachmann-Strauss Dystonia and Parkinson Foundation, Inc., Baylor College of Medicine IDDRC grant 1U54HD083092-01, and NINDS grant 1R01NS089664-01. M.A. is supported by a postdoctoral award from the National Ataxia Foundation (NAF). Becker: E.B. is the recipient of a Research Fellowship from the Royal Society. Dobyns and Millen: This work is supported by NIH grants NS050375 to W.B.D. and NS080390 to K.J.M. Hoshino: I thank Satoshi Miyashita for drawing Fig. 2 . Leto: This work was supported by grants from University of Turin and Research Fund for the Promotion of Basic Research Grant RBFR10A01S. Joyner: I thank my lab members (present and past) for stimulating discussions and Emilie Legué for helpful comments on the manuscript and for drawing Fig. 11 e. Our cerebellar research is supported by grants from the NIH (R37MH085726 and NS092096). Kilpatrick: We thank Mr. George Gagnon for his invaluable and gracious assistance in all aspects of this work. This work was supported by Public Health Services grant NS063047. Sekerková: This work was supported by NIH grant RO1 09904. The authors declare that they have no competing interests.
- Purkinje cells