Abstract
TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.
| Original language | English (US) |
|---|---|
| Pages (from-to) | E195-E197 |
| Journal | Clinical Neurosurgery |
| Volume | 84 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2019 |
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Keywords
- Antiepileptic drugs
- Cerebral metastases
- Craniotomy
- Seizure
PubMed: MeSH publication types
- Journal Article
Cite this
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors. / Chen, Clark C; Rennert, Robert C.; Olson, Jeffrey J.
In: Clinical Neurosurgery, Vol. 84, No. 3, 01.03.2019, p. E195-E197.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors
AU - Chen, Clark C
AU - Rennert, Robert C.
AU - Olson, Jeffrey J.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.
AB - TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.
KW - Antiepileptic drugs
KW - Cerebral metastases
KW - Craniotomy
KW - Seizure
UR - http://www.scopus.com/inward/record.url?scp=85061568345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061568345&partnerID=8YFLogxK
U2 - 10.1093/neuros/nyy545
DO - 10.1093/neuros/nyy545
M3 - Review article
VL - 84
SP - E195-E197
JO - Neurosurgery
JF - Neurosurgery
SN - 0148-396X
IS - 3
ER -