Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors

Clark C. Chen; Robert C. Rennert; Jeffrey J. Olson

doi:10.1093/neuros/nyy545

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors

Clark C. Chen, Robert C. Rennert, Jeffrey J. Olson

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.

Original language	English (US)
Pages (from-to)	E195-E197
Journal	Clinical Neurosurgery
Volume	84
Issue number	3
DOIs	https://doi.org/10.1093/neuros/nyy545
State	Published - Mar 1 2019

Bibliographical note

Funding Information:
These evidence-based clinical practice guidelines were funded exclusively by the Congress of Neurological Surgeons and the Tumor Section of the Congress of Neurological Surgeons and the American Association of Neurological Surgeons, which received no funding from outside commercial sources to support the development of this document.

Publisher Copyright:
© 2019 by the Congress of Neurological Surgeons.

Keywords

Antiepileptic drugs
Cerebral metastases
Craniotomy
Seizure

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10.1093/neuros/nyy545

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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors. / Chen, Clark C.; Rennert, Robert C.; Olson, Jeffrey J.

In: Clinical Neurosurgery, Vol. 84, No. 3, 01.03.2019, p. E195-E197.

Research output: Contribution to journal › Review article › peer-review

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abstract = "TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.",

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AB - TARGET POPULATIONS: Adults with solid brain metastases who have not experienced a seizure. QUESTION 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free? RECOMMENDATION: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free. QUESTION 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting? RECOMMENDATION: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatmentadults-metastatic-brain-tumors/chapter-8.

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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors

Abstract

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