Congenital thyroxine binding globulin deficiency: incidence and inheritance

Malcolm B. Jenkins, Michael W Steffes

Research output: Contribution to journalArticle

14 Scopus citations


Ninety-nine cases of thyroxine binding globulin (TBG) deficiency (90 males and 9 females) were identified among low-T4 infants after newborn hypothyroid screening. The data indicate that inherited TBG deficiency occurs in at least 1: 5,000 newborns (1:2,800 males) and that mild and more pronounced forms are found in approximately equal proportions. Genetic analysis indicates that X-linked inheritance is the usual mode with no suggestion of autosomal inheritance.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalHuman Genetics
Issue number1
StatePublished - Sep 1 1987

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