Congenital Langerhans cell histiocytosis with skin and lung involvement: Spontaneous regression

Varun Aggarwal, Anju Seth, Manjula Jain, Sriram Krishnamurthy, Varkha Chandra, Satinder Aneja

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression. Systemic signs are generally absent. We describe a 4-month-old infant presenting with reddish brown nodular cutaneous lesions since birth with a past history suggestive of pulmonary involvement. Skin biopsy showed a dermal infiltrate of pleomorphic histiocytes; which were CD1a and S-100 positive, consistent with the diagnosis of CSHLCH. Both pulmonary and cutaneous lesions showed spontaneous resolution.

Original languageEnglish (US)
Pages (from-to)811-812
Number of pages2
JournalIndian journal of pediatrics
Volume77
Issue number7
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • Congenital
  • Histiocytosis
  • Pulmonary
  • Skin

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