Abstract
Of the myriad of congenitally and perinatally acquired infections that can impair the neurodevelopment of the infant, cytomegalovirus (CMV) is the most important. In the developed world, congenital CMV infection occurs in approximately 1 % of all pregnancies. Long-term neurodevelopmental disabilities include developmental delay, cerebral palsy, seizure disorders, and sensorineural hearing loss. This chapter summarizes the epidemiology and impact of congenital CMV on brain development. Hypotheses regarding the pathophysiology of CNS injury are reviewed. Prospects for intervention are also summarized.
| Original language | English (US) |
|---|---|
| Title of host publication | Neuroinflammation and Neurodegeneration |
| Publisher | Springer New York |
| Pages | 291-308 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781493910717 |
| ISBN (Print) | 1493910701, 9781493910700 |
| DOIs | |
| State | Published - Apr 1 2014 |
Bibliographical note
Publisher Copyright:© 2014 Springer Science+Business Media New York. All rights reserved.
Keywords
- Congenital cytomegalovirus infection
- Cytome-galovirus vaccine
- Cytomegalovirus
- Cytomegalovirus immune evasion
- Cytomegalovirus neuropathogenesis
- Inflammatory response
- Sensorineural hearing loss