Of the myriad of congenitally and perinatally acquired infections that can impair the neurodevelopment of the infant, cytomegalovirus (CMV) is the most important. In the developed world, congenital CMV infection occurs in approximately 1 % of all pregnancies. Long-term neurodevelopmental disabilities include developmental delay, cerebral palsy, seizure disorders, and sensorineural hearing loss. This chapter summarizes the epidemiology and impact of congenital CMV on brain development. Hypotheses regarding the pathophysiology of CNS injury are reviewed. Prospects for intervention are also summarized.
- Congenital cytomegalovirus infection
- Cytome-galovirus vaccine
- Cytomegalovirus immune evasion
- Cytomegalovirus neuropathogenesis
- Inflammatory response
- Sensorineural hearing loss