Abstract
| Original language | English (US) |
|---|---|
| Volume | 70 |
| State | Published - 2010 |
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Keywords
- *cancer research
- *child
- *congenital disorder
- *hepatoblastoma
- *human
- *oncology
- Beckwith Wiedemann syndrome
- birth weight
- bladder
- case control study
- chromosome aberration
- cleft lip
- confidence interval
- Down syndrome
- familial colon polyposis
- kidney
- liver cancer
- logistic regression analysis
- low birth weight
- microcephaly
- neoplasm
- palate
- register
- rib malformation
- risk
- risk factor
- skin hemangioma
- spinal dysraphism
- telephone interview
Cite this
Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG). / Spector, Logan G; Puumala, Susan E.; Georgieff, Michael K; Krailo, Mark D.; Tomlinson, Gail.
2010.Research output: Book/Report › Book
}
TY - BOOK
T1 - Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG)
AU - Spector, Logan G
AU - Puumala, Susan E.
AU - Georgieff, Michael K
AU - Krailo, Mark D.
AU - Tomlinson, Gail
PY - 2010
Y1 - 2010
N2 - Hepatoblastoma (HB) is a rare pediatric tumor which comprises the majority of liver cancer in children. Previous research has established that Beckwith-Wiedemann Syndrome (BWS) and Familial Adenomatous Polyposis (FAP) predispose to HB, but information on its association with isolated congenital abnormalities is sparse. We examined data from a case-control study of HB conducted through the Children's Oncology Group (COG). Cases were diagnosed by COG institutions during 2000-2008 and controls were recruited from state birth registries, frequency matched for sex, region, year of birth, and low birth weight (a strong risk factor for HB). Data on congenital abnormalities among subjects and covariates were obtained by maternal telephone interview. There were 359 cases and 372 controls included in this analysis, which comprises approximately 90% of the final sample. Odds ratios (OR) and 95% confidence intervals (CI) describing the association between congenital abnormalities with HB, adjusted for birth weight and sex, were calculated using unconditional logistic regression. Twelve cases were reported to have BWS and 4 to have FAP, while no controls had either condition; further analyses excluded abnormalities among children with these syndromes to better examine isolated defects. There was a significant association of HB with kidney, bladder, or sex organ abnormalities (OR = 4.22; 95% CI: 1.57-11.29) which appeared to be specific to kidney/bladder defects (OR = 5.24; 95% CI: 1.40-19.59) but not those of sex organs (OR = 1.58; 95% CI: 0.45-5.55). Elevated but non-significant ORs were found for spina bifida or other spinal defects (OR = 2.39; 95% CI: 0.40-14.07), large or multiple birthmarks (OR = 1.63; 95% CI: 0.97-2.76). No significant associations of cleft lip or palate, Down syndrome or other numerical chromosomal anomalies, microcephaly, or rib abnormalities, although
AB - Hepatoblastoma (HB) is a rare pediatric tumor which comprises the majority of liver cancer in children. Previous research has established that Beckwith-Wiedemann Syndrome (BWS) and Familial Adenomatous Polyposis (FAP) predispose to HB, but information on its association with isolated congenital abnormalities is sparse. We examined data from a case-control study of HB conducted through the Children's Oncology Group (COG). Cases were diagnosed by COG institutions during 2000-2008 and controls were recruited from state birth registries, frequency matched for sex, region, year of birth, and low birth weight (a strong risk factor for HB). Data on congenital abnormalities among subjects and covariates were obtained by maternal telephone interview. There were 359 cases and 372 controls included in this analysis, which comprises approximately 90% of the final sample. Odds ratios (OR) and 95% confidence intervals (CI) describing the association between congenital abnormalities with HB, adjusted for birth weight and sex, were calculated using unconditional logistic regression. Twelve cases were reported to have BWS and 4 to have FAP, while no controls had either condition; further analyses excluded abnormalities among children with these syndromes to better examine isolated defects. There was a significant association of HB with kidney, bladder, or sex organ abnormalities (OR = 4.22; 95% CI: 1.57-11.29) which appeared to be specific to kidney/bladder defects (OR = 5.24; 95% CI: 1.40-19.59) but not those of sex organs (OR = 1.58; 95% CI: 0.45-5.55). Elevated but non-significant ORs were found for spina bifida or other spinal defects (OR = 2.39; 95% CI: 0.40-14.07), large or multiple birthmarks (OR = 1.63; 95% CI: 0.97-2.76). No significant associations of cleft lip or palate, Down syndrome or other numerical chromosomal anomalies, microcephaly, or rib abnormalities, although
KW - cancer research
KW - child
KW - congenital disorder
KW - hepatoblastoma
KW - human
KW - oncology
KW - Beckwith Wiedemann syndrome
KW - birth weight
KW - bladder
KW - case control study
KW - chromosome aberration
KW - cleft lip
KW - confidence interval
KW - Down syndrome
KW - familial colon polyposis
KW - kidney
KW - liver cancer
KW - logistic regression analysis
KW - low birth weight
KW - microcephaly
KW - neoplasm
KW - palate
KW - register
KW - rib malformation
KW - risk
KW - risk factor
KW - skin hemangioma
KW - spinal dysraphism
KW - telephone interview
M3 - Book
VL - 70
BT - Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG)
ER -