Conformationally restricted paclitaxel analogues

Macrocyclic mimics of the 'hydrophobic collapse' conformation

Thomas C. Boge, Zhi Jun Wu, Richard H. Himes, David G. Vander Velde, Gunda Georg

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group the 2-benzoate moiety with two-atom tethers to mimic the 'hydrophobic collapse' paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.

Original languageEnglish (US)
Pages (from-to)3047-3052
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number20
DOIs
StatePublished - Oct 18 1999
Externally publishedYes

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Paclitaxel
Conformations
Benzoates
Tubulin
Assays
Atoms

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Conformationally restricted paclitaxel analogues : Macrocyclic mimics of the 'hydrophobic collapse' conformation. / Boge, Thomas C.; Wu, Zhi Jun; Himes, Richard H.; Vander Velde, David G.; Georg, Gunda.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 20, 18.10.1999, p. 3047-3052.

Research output: Contribution to journalArticle

Boge, Thomas C. ; Wu, Zhi Jun ; Himes, Richard H. ; Vander Velde, David G. ; Georg, Gunda. / Conformationally restricted paclitaxel analogues : Macrocyclic mimics of the 'hydrophobic collapse' conformation. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 20. pp. 3047-3052.
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