Conformational transitions of immobilized DNA chains driven by pH with electrochemical output

Fanben Meng, Yuexing Liu, Lei Liu, Genxi Li

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A pH-driven DNA sway rod is prepared by immobilizing thiolated DNA, mercaptohexanol, and cysteine on a gold electrode surface. As pH changes around the pI of cysteine, contrary electrostatic effect is produced between the negative DNA and amphoteric cysteine, which actuates reversible conformational transitions, such as sway of the DNA molecules, rodlike chain-to-globule, and so forth, The nanoscale motion can be detected by commonly used electrochemical technique and reversible electrochemical signal may be observed.

Original languageEnglish (US)
Pages (from-to)894-896
Number of pages3
JournalJournal of Physical Chemistry B
Volume113
Issue number4
DOIs
StatePublished - Jan 29 2009

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