Conformational studies of peptide-amphiphiles based on hydroxyapatite nucleation motifs

Nathan Lockwood, Kevin H Mayo, Matthew Tirrell

Research output: Contribution to journalArticle

Abstract

Our work centers on understanding the stereochemical relationships between these domains and hydroxyapatite crystals in order to extrapolate the underlying principles to new biomaterials. We have incorporated several short phosphoryn protein sequences and analog into 'peptide-amphiphiles' by covalently linking the N-terminus of the peptide to lipid tails. The combination of CD and NMR structural data and nucleation properties will eventually be used to develop a model of the stereochemical relationships between peptide templates and hydroxyapatite crystals.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000

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