Conformational change of hydroxyapatite/gelatin nanocomposite by glutaraldehyde

Myung Chul Chang, Ching Chang Ko, William H. Douglas

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107 Scopus citations


The hydroxyapatite (HAp)/gelatin (GEL) nanocomposite was prepared through the coprecipitation and then cross-linked by using glutaraldehyde (GA). From FT-IR measurement the spectral features for amide bands and phosphate bands were severely modified by the cross-linkage and the organic content increased with the degree of cross-linkage. From Transmission Electron Microscopy (TEM) and electron diffraction analyses we could confirm the preferentially directional growth of needle-like HAp particles, which were embedded in GEL by the mineralization. Also we could observe worm-like stria patterns of contrast, which were revealed by the mineralization on the individual GEL fibrils. Moiré images were observed in a highly cross-linked HAp/GEL nanocomposite sample and we think the cross-linkage induced the assembly of unordered individual fibrils along the preferential direction.

Original languageEnglish (US)
Pages (from-to)3087-3094
Number of pages8
Issue number18
StatePublished - Aug 2003

Bibliographical note

Funding Information:
The authors greatly appreciate Dr. Stuart Mckernan for TEM work and thank Mr. Kevin Cummings for DT/TGA measurement. This study was partially supported by MDRCBB and 3M ESPE Dental Products.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Conformation
  • Cross-linkage
  • Hydroxyapatite-gelatin nanocomposite
  • Moiré's fringe


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