Conformation of [1-13C,15N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy

Robert C. Anderson; Edwin B. Villhauer; Hans Peter Weber; Terry Gullion; Jim M. Joers; Michael Shapiro

doi:10.1021/ja00147a016

Conformation of [1-¹³C,¹⁵N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy

Robert C. Anderson
, Edwin B. Villhauer
, Hans Peter Weber
, Terry Gullion
, Jim M. Joers
, Michael Shapiro

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The conformation of [1-¹³C,¹⁵N]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.

Original language	English (US)
Pages (from-to)	10546-10550
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	117
Issue number	42
DOIs	https://doi.org/10.1021/ja00147a016
State	Published - 1995
Externally published	Yes

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10.1021/ja00147a016

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title = "Conformation of [1-13C,15N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy",

abstract = "The conformation of [1-13C,15N]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.",

author = "Anderson, \{Robert C.\} and Villhauer, \{Edwin B.\} and Weber, \{Hans Peter\} and Terry Gullion and Joers, \{Jim M.\} and Michael Shapiro",

year = "1995",

doi = "10.1021/ja00147a016",

language = "English (US)",

volume = "117",

pages = "10546--10550",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "42",

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T1 - Conformation of [1-13C,15N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy

AU - Anderson, Robert C.

AU - Villhauer, Edwin B.

AU - Weber, Hans Peter

AU - Gullion, Terry

AU - Joers, Jim M.

AU - Shapiro, Michael

PY - 1995

Y1 - 1995

N2 - The conformation of [1-13C,15N]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.

AB - The conformation of [1-13C,15N]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.

UR - https://www.scopus.com/pages/publications/0028788086

UR - https://www.scopus.com/pages/publications/0028788086#tab=citedBy

U2 - 10.1021/ja00147a016

DO - 10.1021/ja00147a016

M3 - Article

AN - SCOPUS:0028788086

SN - 0002-7863

VL - 117

SP - 10546

EP - 10550

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 42

ER -

Conformation of [1-¹³C,¹⁵N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy

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