Conformation of [1-13C,15N]Acetyl-L-carnitine. Rotational-Echo, Double-Resonance Nuclear Magnetic Resonance Spectroscopy

Robert C. Anderson, Edwin B. Villhauer, Hans Peter Weber, Terry Gullion, Jim M. Joers, Michael Shapiro

Research output: Contribution to journalArticlepeer-review

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The conformation of [1-13C,15N]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.

Original languageEnglish (US)
Pages (from-to)10546-10550
Number of pages5
JournalJournal of the American Chemical Society
Issue number42
StatePublished - 1995
Externally publishedYes


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