Confidence estimation and the size of a clinical trial

Richard B. McHugh, Chap T Le

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The general procedure for sample size determination based upon the confidence interval approach is reviewed and presented for both absolute and relative precision stipulations. The relationship between precision and sample size is discussed and methods for sample size determination for clinical trials are presented and illustrated with numerical examples.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalControlled Clinical Trials
Issue number2
StatePublished - Jun 1984


  • Confidence estimation
  • precision
  • sample size determination

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