Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Robert C. Rennert, Reid R. Hoshide, Jason W. Signorelli, Deirdre Amaro, Jayson A. Sack, Cameron W. Brennan, Clark C. Chen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.

Original languageEnglish (US)
Pages (from-to)1472-1478
Number of pages7
JournalJournal of neurosurgery
Volume126
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • Chromothripsis
  • Glioblastoma
  • Metastasis
  • Oncology

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