Concordance between epidermal nerve fiber density and sensory examination in patients with symptoms of idiopathic small fiber neuropathy

David Walk, Gwen Wendelschafer-Crabb, Cynthia S Davey, William R Kennedy

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48 Citations (Scopus)

Abstract

Quantitation of epidermal nerve fiber (ENF) density is an objective diagnostic test of small fiber neuropathy (SFN). For a diagnostic test to be clinically useful it should correspond well with clinically meaningful physical findings. We performed a retrospective analysis of the concordance between foot ENF density and clinical findings in all patients seen at our institution with possible idiopathic SFN who underwent skin biopsy for ENF density determination. We found a high concordance between reduced foot ENF density and loss of pinprick sensitivity in this patient population. Our findings indicate that ENF density determination is a clinically relevant objective test in patients undergoing evaluation for possible SFN.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of the Neurological Sciences
Volume255
Issue number1-2
DOIs
StatePublished - Apr 15 2007

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Nerve Fibers
Routine Diagnostic Tests
Foot
Small Fiber Neuropathy
Biopsy
Skin
Population

Keywords

  • Epidermal nerve fiber density
  • Painful neuropathy
  • Pinprick testing
  • Skin biopsy
  • Small fiber neuropathy

Cite this

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abstract = "Quantitation of epidermal nerve fiber (ENF) density is an objective diagnostic test of small fiber neuropathy (SFN). For a diagnostic test to be clinically useful it should correspond well with clinically meaningful physical findings. We performed a retrospective analysis of the concordance between foot ENF density and clinical findings in all patients seen at our institution with possible idiopathic SFN who underwent skin biopsy for ENF density determination. We found a high concordance between reduced foot ENF density and loss of pinprick sensitivity in this patient population. Our findings indicate that ENF density determination is a clinically relevant objective test in patients undergoing evaluation for possible SFN.",
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AU - Davey, Cynthia S

AU - Kennedy, William R

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AB - Quantitation of epidermal nerve fiber (ENF) density is an objective diagnostic test of small fiber neuropathy (SFN). For a diagnostic test to be clinically useful it should correspond well with clinically meaningful physical findings. We performed a retrospective analysis of the concordance between foot ENF density and clinical findings in all patients seen at our institution with possible idiopathic SFN who underwent skin biopsy for ENF density determination. We found a high concordance between reduced foot ENF density and loss of pinprick sensitivity in this patient population. Our findings indicate that ENF density determination is a clinically relevant objective test in patients undergoing evaluation for possible SFN.

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KW - Pinprick testing

KW - Skin biopsy

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