Abstract
A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 955-958 |
| Number of pages | 4 |
| Journal | Journal of Heterocyclic Chemistry |
| Volume | 50 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2013 |
