Concise synthesis of α-methylene-β-hydroxy-γ-carboxy- γ-lactams

Srinivas Tekkam, Joseph L. Johnson, Subash C. Jonnalagadda, Venkatram R. Mereddy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. All the synthesized compounds have been evaluated for their cytotoxicity on multiple myeloma cancer cell lines.

Original languageEnglish (US)
Pages (from-to)955-958
Number of pages4
JournalJournal of Heterocyclic Chemistry
Issue number4
StatePublished - Jul 1 2013


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