Conceptual model for using imidazoline derivative solutions in pulpal management

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Alpha-adrenergic agonists, such as the Imidazoline derivatives (ImDs) of oxymetazoline and xylometazoline, are highly effective hemostatic agents. ImDs have not been widely used in dentistry but their use in medicine, specifically in ophthalmology and otolaryngology, warrants consideration for pulpal hemostasis. This review presents dental healthcare professionals with an overview of ImDs in medicine. ImD solutions have the potential to be more effective and biocompatible than existing topical hemostatic compounds in pulpal management. Through a comprehensive analysis of the pharmacology of ImDs and the microphysiology of hemostasis regulation in oral tissues, a conceptual model of pulpal management by ImD solutions is presented.

Original languageEnglish (US)
Article number1212
Pages (from-to)1-11
Number of pages11
JournalJournal of Clinical Medicine
Issue number6
StatePublished - Mar 15 2021

Bibliographical note

Publisher Copyright:
© 2021 by the author. Licensee MDPI, Basel, Switzerland.


  • Alpha-adrenergic agonists
  • Apexogenesis
  • Dental pulp
  • Dentistry
  • Direct pulp cap
  • Hemostasis
  • Imidazoline
  • Mucosa
  • Nasal
  • Oxymetazoline
  • Pulpotomy


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