Concentration-dependent conditioned place preference to inhaled toluene vapors in rats

Dianne E. Lee, Madina R. Gerasimov, Wynne K. Schiffer, Andrew N. Gifford

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objectives: Toluene is present in many commercial products and is subject to abuse by inhalation. The goal of this study was to extend previous reports indicating that rats will exhibit a positive conditioned place preference to inhaled toluene vapors and to determine the dose-response relationship for inhaled toluene in terms of exposure concentration and number of exposures. For the conditioned place preference experiments rats were exposed to toluene vapors at concentrations of 800, 2000, 3000 or 5000 ppm in one compartment of a three-compartment box. Results: Following six conditioning sessions with toluene, a significant place preference was obtained at 2000 and 3000 ppm, but not at 800 or 5000 ppm. Extending the number of toluene pairings at the 2000 and 3000 ppm concentration to 12 significantly enhanced the place preference compared to that at six pairings. Conclusions: These experiments extend our previous finding that rats will show a conditioned place preference to inhaled toluene, and indicate that a reinforcing "dose" of toluene depends on both the concentration and number of pairings.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalDrug and alcohol dependence
Issue number1
StatePublished - Oct 15 2006

Bibliographical note

Funding Information:
Supported by National Institute of Health grant DA017349 and performed under Brookhaven Science Associates contract No. DE-AC02-98CH10886 with the U.S. Department of Energy.


  • Conditioned place preference
  • Drugs-of-abuse
  • Inhalant abuse
  • Rats
  • Toluene


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