Computer-aided rational drug design: A novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling

Wan Ru Chao; Dawn Yean; Khalid Amin; Carol Green; Ling Jong

doi:10.1021/jm070040e

Computer-aided rational drug design: A novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling

Wan Ru Chao, Dawn Yean, Khalid Amin, Carol Green, Ling Jong

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

Indole-3-carbinol (I3C) is a naturally occurring anticancer agent and has entered clinical trials for cancer prevention. However, the clinical development of I3C has been impeded by its poor metabolic profile. The active components of I3C were used to develop a novel class of indole analogs to optimize I3C's anticancer actions, including blocking growth factor-stimulated Akt activation. The most promising of these analogs, SRI3668, exhibited potent oral anticancer activity against various cancers and no significant toxicity.

Original language	English (US)
Pages (from-to)	3412-3415
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	50
Issue number	15
DOIs	https://doi.org/10.1021/jm070040e
State	Published - Jul 26 2007

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AU - Green, Carol

AU - Jong, Ling

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Computer-aided rational drug design: A novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling

Abstract

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