Computer-aided rational drug design: A novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling

Wan Ru Chao, Dawn Yean, Khalid Amin, Carol Green, Ling Jong

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Indole-3-carbinol (I3C) is a naturally occurring anticancer agent and has entered clinical trials for cancer prevention. However, the clinical development of I3C has been impeded by its poor metabolic profile. The active components of I3C were used to develop a novel class of indole analogs to optimize I3C's anticancer actions, including blocking growth factor-stimulated Akt activation. The most promising of these analogs, SRI3668, exhibited potent oral anticancer activity against various cancers and no significant toxicity.

Original languageEnglish (US)
Pages (from-to)3412-3415
Number of pages4
JournalJournal of medicinal chemistry
Volume50
Issue number15
DOIs
StatePublished - Jul 26 2007

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