Computed tomography (CT) assessment of the membranous septal anatomy prior to transcatheter aortic valve replacement (TAVR) with the balloon-expandable SAPIEN 3 valve

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Abstract

Objectives: The lower limit of the membranous septum (MS) is considered an anatomic landmark for the emergence of the Bundle of His into the left ventricle. Computed tomography (CT) assessment of MS anatomy may provide useful information about the risk of conduction abnormalities following transcatheter aortic valve replacement (TAVR). Methods and results: The study included 102 consecutive patients undergoing TAVR with the Edwards Sapien 3 (S3) valve. Using pre-TAVR CT and post-procedure angiography we evaluated for the presence of calcium in the left ventricular outflow tract (LVOT), calcium depth (CD), implantation depth (ID) and MS length. The MS length minus the prosthesis ID was calculated (Delta MSID). Outcomes included new left bundle branch block (LBBB) or permanent pacemaker (PPM) within 30 days. Seventeen patients (17%) received a PPM and 28 (27%) developed new LBBB following TAVR. Mean (± SD) MS length and delta MSID were 7.5 mm (2) and 0.9 mm (4.5), respectively. Twenty-one patients (20%) had calcium in the device landing zone and the mean (SD) CD was 6.8 mm (± 4). Calcium in the device landing zone (37% versus 16%, p = 0.02) and implantation depth (6 mm (4–8) versus 4 mm (4–5), p = 0.02) predicted new conduction abnormalities after TAVR. Conclusions: The presence of calcium in the device landing zone is associated with increased risk of conduction abnormalities after TAVR with S3. In such cases, a more aortic deployment of the prosthesis may be warranted.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume19
Issue number5
DOIs
StatePublished - Jul 1 2018

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Anatomy
Tomography
Calcium
Bundle-Branch Block
Equipment and Supplies
Prosthesis Implantation
Anatomic Landmarks
Bundle of His
Prostheses and Implants
Heart Ventricles
Transcatheter Aortic Valve Replacement
Angiography

Keywords

  • Conduction abnormality
  • Transcatheter heart valve

PubMed: MeSH publication types

  • Journal Article

Cite this

@article{7dda0d90e6f74cf0b49fa848e05cbd07,
title = "Computed tomography (CT) assessment of the membranous septal anatomy prior to transcatheter aortic valve replacement (TAVR) with the balloon-expandable SAPIEN 3 valve",
abstract = "Objectives: The lower limit of the membranous septum (MS) is considered an anatomic landmark for the emergence of the Bundle of His into the left ventricle. Computed tomography (CT) assessment of MS anatomy may provide useful information about the risk of conduction abnormalities following transcatheter aortic valve replacement (TAVR). Methods and results: The study included 102 consecutive patients undergoing TAVR with the Edwards Sapien 3 (S3) valve. Using pre-TAVR CT and post-procedure angiography we evaluated for the presence of calcium in the left ventricular outflow tract (LVOT), calcium depth (CD), implantation depth (ID) and MS length. The MS length minus the prosthesis ID was calculated (Delta MSID). Outcomes included new left bundle branch block (LBBB) or permanent pacemaker (PPM) within 30 days. Seventeen patients (17{\%}) received a PPM and 28 (27{\%}) developed new LBBB following TAVR. Mean (± SD) MS length and delta MSID were 7.5 mm (2) and 0.9 mm (4.5), respectively. Twenty-one patients (20{\%}) had calcium in the device landing zone and the mean (SD) CD was 6.8 mm (± 4). Calcium in the device landing zone (37{\%} versus 16{\%}, p = 0.02) and implantation depth (6 mm (4–8) versus 4 mm (4–5), p = 0.02) predicted new conduction abnormalities after TAVR. Conclusions: The presence of calcium in the device landing zone is associated with increased risk of conduction abnormalities after TAVR with S3. In such cases, a more aortic deployment of the prosthesis may be warranted.",
keywords = "Conduction abnormality, Transcatheter heart valve",
author = "Oestreich, {Brett A} and Mackenzi Mbai and Gurevich, {Sergey G} and Nijjar, {Prabhjot S} and Selcuk Adabag and Bertog, {Stefan C} and Kelly, {Rosemary F} and Santiago Garcia",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.carrev.2017.12.012",
language = "English (US)",
volume = "19",
pages = "626--631",
journal = "Cardiovascular Revascularization Medicine",
issn = "1553-8389",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Computed tomography (CT) assessment of the membranous septal anatomy prior to transcatheter aortic valve replacement (TAVR) with the balloon-expandable SAPIEN 3 valve

AU - Oestreich, Brett A

AU - Mbai, Mackenzi

AU - Gurevich, Sergey G

AU - Nijjar, Prabhjot S

AU - Adabag, Selcuk

AU - Bertog, Stefan C

AU - Kelly, Rosemary F

AU - Garcia, Santiago

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Objectives: The lower limit of the membranous septum (MS) is considered an anatomic landmark for the emergence of the Bundle of His into the left ventricle. Computed tomography (CT) assessment of MS anatomy may provide useful information about the risk of conduction abnormalities following transcatheter aortic valve replacement (TAVR). Methods and results: The study included 102 consecutive patients undergoing TAVR with the Edwards Sapien 3 (S3) valve. Using pre-TAVR CT and post-procedure angiography we evaluated for the presence of calcium in the left ventricular outflow tract (LVOT), calcium depth (CD), implantation depth (ID) and MS length. The MS length minus the prosthesis ID was calculated (Delta MSID). Outcomes included new left bundle branch block (LBBB) or permanent pacemaker (PPM) within 30 days. Seventeen patients (17%) received a PPM and 28 (27%) developed new LBBB following TAVR. Mean (± SD) MS length and delta MSID were 7.5 mm (2) and 0.9 mm (4.5), respectively. Twenty-one patients (20%) had calcium in the device landing zone and the mean (SD) CD was 6.8 mm (± 4). Calcium in the device landing zone (37% versus 16%, p = 0.02) and implantation depth (6 mm (4–8) versus 4 mm (4–5), p = 0.02) predicted new conduction abnormalities after TAVR. Conclusions: The presence of calcium in the device landing zone is associated with increased risk of conduction abnormalities after TAVR with S3. In such cases, a more aortic deployment of the prosthesis may be warranted.

AB - Objectives: The lower limit of the membranous septum (MS) is considered an anatomic landmark for the emergence of the Bundle of His into the left ventricle. Computed tomography (CT) assessment of MS anatomy may provide useful information about the risk of conduction abnormalities following transcatheter aortic valve replacement (TAVR). Methods and results: The study included 102 consecutive patients undergoing TAVR with the Edwards Sapien 3 (S3) valve. Using pre-TAVR CT and post-procedure angiography we evaluated for the presence of calcium in the left ventricular outflow tract (LVOT), calcium depth (CD), implantation depth (ID) and MS length. The MS length minus the prosthesis ID was calculated (Delta MSID). Outcomes included new left bundle branch block (LBBB) or permanent pacemaker (PPM) within 30 days. Seventeen patients (17%) received a PPM and 28 (27%) developed new LBBB following TAVR. Mean (± SD) MS length and delta MSID were 7.5 mm (2) and 0.9 mm (4.5), respectively. Twenty-one patients (20%) had calcium in the device landing zone and the mean (SD) CD was 6.8 mm (± 4). Calcium in the device landing zone (37% versus 16%, p = 0.02) and implantation depth (6 mm (4–8) versus 4 mm (4–5), p = 0.02) predicted new conduction abnormalities after TAVR. Conclusions: The presence of calcium in the device landing zone is associated with increased risk of conduction abnormalities after TAVR with S3. In such cases, a more aortic deployment of the prosthesis may be warranted.

KW - Conduction abnormality

KW - Transcatheter heart valve

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U2 - 10.1016/j.carrev.2017.12.012

DO - 10.1016/j.carrev.2017.12.012

M3 - Article

VL - 19

SP - 626

EP - 631

JO - Cardiovascular Revascularization Medicine

JF - Cardiovascular Revascularization Medicine

SN - 1553-8389

IS - 5

ER -