Computational analysis of functionally related genes in mouse response to plasmodium chabaudi

Viviane Tchonang Leuche, Ahmed Tewfik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

According to the World Health Organization (WHO), over 1-3 million children under the age of five die due to malaria each year. The aim of this project is to increase our understanding of the Plasmodium chabaudi parasite and of its interactions with the mammalian host using a computational approach. This is achieved by applying a time-series clustering algorithm to a publicly available short time-series gene expression data representing two disease states (P. chabaudi infected and non infected), two genders (male and female), two protocols (intact and gonadectomized), and four time points (0, 3, 7, and 14 days after inoculation) of Mus musculus (mouse) response to P. chabaudi infection. Results obtained provide a rigorous statistical explanation to the fact that intact males were more likely than intact females to die following P. chabaudi infection on one hand, and on the other hand, gonadectomy of male and female mice altered these sex-associated differences. These findings may suggest that sex steroid hormone modulates immune responses to pathogen attacks.

Original languageEnglish (US)
Title of host publication2009 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2009
DOIs
StatePublished - 2009
Event2009 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2009 - Minneapolis, MN, United States
Duration: May 17 2009May 21 2009

Publication series

Name2009 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2009

Other

Other2009 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2009
Country/TerritoryUnited States
CityMinneapolis, MN
Period5/17/095/21/09

Fingerprint

Dive into the research topics of 'Computational analysis of functionally related genes in mouse response to plasmodium chabaudi'. Together they form a unique fingerprint.

Cite this