Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation

Katharine M. Brauch, Lin Y. Chen, Timothy M. Olson

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Atrial fibrillation (AF) is a heritable, genetically heterogeneous disorder. To identify gene defects that cause or confer susceptibility to AF, a cohort of 268 unrelated patients with idiopathic forms of familial and sporadic AF was recruited. LMNA, encoding the nuclear membrane proteins, lamin A/C, was selected as a candidate gene for lone AF based on its established association with a syndrome of dilated cardiomyopathy, conduction system disease, and AF. Comprehensive mutation scanning identified only 1 potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted.

Original languageEnglish (US)
Pages (from-to)1426-1428
Number of pages3
JournalAmerican Journal of Cardiology
Issue number10
StatePublished - May 15 2009


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