Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma

Dina Bassiouny, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang I. Lu, Elzbieta Slodkowska, Carlos Parra-Herran, Hak Fai Chiu, Magda Naeim, Nim Li, Mahmoud A Khalifa, Sharon Nofech-Mozes

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11.1%). P53 was aberrant in 10 (27.8%); none overexpressed p16. HER2 was positive in 6/35 (17.1%). Most PMOCs had a favorable outcome. However, recurrence is usually fatal. The typical tumor profile was CK7+, CK20+/−, CDX2+/−, PAX8−, ER−, PgR−, and SATB2−. HER2 positivity suggests a possible target for therapy in advanced disease.

Original languageEnglish (US)
Pages (from-to)306-317
Number of pages12
JournalInternational Journal of Surgical Pathology
Volume26
Issue number4
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

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Mucinous Adenocarcinoma
Recurrence
Therapeutics
Neoplasms
Proteins

Keywords

  • HER2
  • HNF1b
  • PAX8
  • SATB2
  • immunohistochemistry
  • mucinous
  • napsin A
  • ovarian cancer

PubMed: MeSH publication types

  • Journal Article

Cite this

Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma. / Bassiouny, Dina; Ismiil, Nadia; Dubé, Valerie; Han, Guangming; Cesari, Matthew; Lu, Fang I.; Slodkowska, Elzbieta; Parra-Herran, Carlos; Chiu, Hak Fai; Naeim, Magda; Li, Nim; Khalifa, Mahmoud A; Nofech-Mozes, Sharon.

In: International Journal of Surgical Pathology, Vol. 26, No. 4, 01.06.2018, p. 306-317.

Research output: Contribution to journal › Article

Bassiouny, D, Ismiil, N, Dubé, V, Han, G, Cesari, M, Lu, FI, Slodkowska, E, Parra-Herran, C, Chiu, HF, Naeim, M, Li, N, Khalifa, MA & Nofech-Mozes, S 2018, 'Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma' International Journal of Surgical Pathology, vol. 26, no. 4, pp. 306-317. https://doi.org/10.1177/1066896917752861
Bassiouny D, Ismiil N, Dubé V, Han G, Cesari M, Lu FI et al. Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma. International Journal of Surgical Pathology. 2018 Jun 1;26(4):306-317. https://doi.org/10.1177/1066896917752861
Bassiouny, Dina ; Ismiil, Nadia ; Dubé, Valerie ; Han, Guangming ; Cesari, Matthew ; Lu, Fang I. ; Slodkowska, Elzbieta ; Parra-Herran, Carlos ; Chiu, Hak Fai ; Naeim, Magda ; Li, Nim ; Khalifa, Mahmoud A ; Nofech-Mozes, Sharon. / Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma. In: International Journal of Surgical Pathology. 2018 ; Vol. 26, No. 4. pp. 306-317.
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