Comprehensive assessment of oxidatively induced modifications of DNA in a rat model of human Wilson's disease

Keyphrases

• Rat Model 100%
• Comprehensive Assessment 100%
• Wilson Disease 100%
• Long-Evans 100%
• 5-ethynyl-2′-deoxyuridine 60%
• Agouti 60%
• Liver Tissue 40%
• 2′-Deoxyguanosine 40%
• DNA Lesions 40%
• Cinnamon 40%
• Oxidative Stress 20%
• Hepatocytes 20%
• Stress-induced 20%
• Gene Regulation 20%
• Genome Stability 20%
• Lipid Peroxidation 20%
• TET Proteins 20%
• DNA Modification 20%
• Epigenetic Pathways 20%
• Purine 20%
• Microgram 20%
• Oxidation Products 20%
• Reactive Oxygen Species Production 20%
• Isotope Dilution 20%
• Tandem Mass Spectrometry 20%
• Fenton Reaction 20%
• Cause of Disease 20%
• Long-Evans Rats 20%
• Cu2+ 20%
• Deoxyadenosine 20%
• Simultaneous Quantification 20%
• 2′-deoxyadenosine 20%
• In Vitro Biochemical Assay 20%
• Nanospray Desorption Electrospray Ionization (nano-DESI) 20%
• Cyclonucleosides 20%
• Copper Accumulation 20%
• Nanoflow Liquid Chromatography 20%
• Copper Excretion 20%
• Copper Ions 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Rat Model 100%
• Agouti 100%
• Wilson's Disease 100%
• 5 Methyldeoxycytidine 66%
• Deoxyguanosine 66%
• Deoxyadenosine 66%
• Long Evans Cinnamon Rat 33%
• Reactive Oxygen Metabolite 33%
• Copper Ion 33%
• Deoxycytidine 33%
• Purine 33%
• Cuprous Ion 33%