Compounds that confer thermal stress resistance and extended lifespan

Michael G. Benedetti; Amanda L. Foster; Maithili C. Vantipalli; Mark P. White; James N. Sampayo; Matthew S. Gill; Anders Olsen; Gordon J. Lithgow

doi:10.1016/j.exger.2008.08.049

Compounds that confer thermal stress resistance and extended lifespan

Michael G. Benedetti
, Amanda L. Foster
, Maithili C. Vantipalli
, Mark P. White
, James N. Sampayo
, Matthew S. Gill
, Anders Olsen
, Gordon J. Lithgow

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemical modulators of aging in model organisms could prompt new strategies for attacking age-related disease such as diabetes, cancer and neurodegenerative disorders [Collins, J.J., Evason, K., Kornfeld, K., 2006. Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp. Gerontol.; Floyd, R.A., 2006. Nitrones as therapeutics in age-related diseases. Aging Cell 5, 51-57; Gill, M.S., 2006. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 5, 23-30; Hefti, F.F., Bales, R., 2006. Regulatory issues in aging pharmacology. Aging Cell 5, 3-8]. Resistance to multiple types of stress is a common trait in long-lived genetic variants of a number of species; therefore, we have tested compounds that act as stress response mimetics. We have focused on compounds with antioxidant properties and identified those that confer thermal stress resistance in the nematode Caenorhabditis elegans. Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging.

Original language	English (US)
Pages (from-to)	882-891
Number of pages	10
Journal	Experimental Gerontology
Volume	43
Issue number	10
DOIs	https://doi.org/10.1016/j.exger.2008.08.049
State	Published - Oct 2008
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank members of the Lithgow Lab for helpful discussions. CYP35A3 was a gift from Ralph Menzel. G.J.L. is supported by the NIH AG21069, AG22868, NS050789-01, the Ellison Medical Foundation and the Larry L. Hillblom Foundation. The COPAS BIOSORT system was a generous gift from The Glenn Foundation for Medical Research and The Herbert Simon Foundation. Nematode strains were obtained from the Caenorhabditis Genetics Center, funded by the National Institutes of Health National Center for Research Resources.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aging
Antioxidant
Compound screen
Lifespan
Lipoic acid
Propyl gallate
Stress
Taxifolin
Thermotolerance
Trolox

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10.1016/j.exger.2008.08.049

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title = "Compounds that confer thermal stress resistance and extended lifespan",

abstract = "The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemical modulators of aging in model organisms could prompt new strategies for attacking age-related disease such as diabetes, cancer and neurodegenerative disorders [Collins, J.J., Evason, K., Kornfeld, K., 2006. Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp. Gerontol.; Floyd, R.A., 2006. Nitrones as therapeutics in age-related diseases. Aging Cell 5, 51-57; Gill, M.S., 2006. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 5, 23-30; Hefti, F.F., Bales, R., 2006. Regulatory issues in aging pharmacology. Aging Cell 5, 3-8]. Resistance to multiple types of stress is a common trait in long-lived genetic variants of a number of species; therefore, we have tested compounds that act as stress response mimetics. We have focused on compounds with antioxidant properties and identified those that confer thermal stress resistance in the nematode Caenorhabditis elegans. Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging.",

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author = "Benedetti, \{Michael G.\} and Foster, \{Amanda L.\} and Vantipalli, \{Maithili C.\} and White, \{Mark P.\} and Sampayo, \{James N.\} and Gill, \{Matthew S.\} and Anders Olsen and Lithgow, \{Gordon J.\}",

note = "Funding Information: The authors thank members of the Lithgow Lab for helpful discussions. CYP35A3 was a gift from Ralph Menzel. G.J.L. is supported by the NIH AG21069, AG22868, NS050789-01, the Ellison Medical Foundation and the Larry L. Hillblom Foundation. The COPAS BIOSORT system was a generous gift from The Glenn Foundation for Medical Research and The Herbert Simon Foundation. Nematode strains were obtained from the Caenorhabditis Genetics Center, funded by the National Institutes of Health National Center for Research Resources.",

year = "2008",

month = oct,

doi = "10.1016/j.exger.2008.08.049",

language = "English (US)",

volume = "43",

pages = "882--891",

journal = "Experimental Gerontology",

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AU - Sampayo, James N.

AU - Gill, Matthew S.

AU - Olsen, Anders

AU - Lithgow, Gordon J.

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N2 - The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemical modulators of aging in model organisms could prompt new strategies for attacking age-related disease such as diabetes, cancer and neurodegenerative disorders [Collins, J.J., Evason, K., Kornfeld, K., 2006. Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp. Gerontol.; Floyd, R.A., 2006. Nitrones as therapeutics in age-related diseases. Aging Cell 5, 51-57; Gill, M.S., 2006. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 5, 23-30; Hefti, F.F., Bales, R., 2006. Regulatory issues in aging pharmacology. Aging Cell 5, 3-8]. Resistance to multiple types of stress is a common trait in long-lived genetic variants of a number of species; therefore, we have tested compounds that act as stress response mimetics. We have focused on compounds with antioxidant properties and identified those that confer thermal stress resistance in the nematode Caenorhabditis elegans. Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging.

AB - The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemical modulators of aging in model organisms could prompt new strategies for attacking age-related disease such as diabetes, cancer and neurodegenerative disorders [Collins, J.J., Evason, K., Kornfeld, K., 2006. Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp. Gerontol.; Floyd, R.A., 2006. Nitrones as therapeutics in age-related diseases. Aging Cell 5, 51-57; Gill, M.S., 2006. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 5, 23-30; Hefti, F.F., Bales, R., 2006. Regulatory issues in aging pharmacology. Aging Cell 5, 3-8]. Resistance to multiple types of stress is a common trait in long-lived genetic variants of a number of species; therefore, we have tested compounds that act as stress response mimetics. We have focused on compounds with antioxidant properties and identified those that confer thermal stress resistance in the nematode Caenorhabditis elegans. Some of these compounds (lipoic acid, propyl gallate, trolox and taxifolin) also extend the normal lifespan of this simple invertebrate, consistent with the general model that enhanced stress resistance slows aging.

KW - Aging

KW - Antioxidant

KW - Compound screen

KW - Lifespan

KW - Lipoic acid

KW - Propyl gallate

KW - Stress

KW - Taxifolin

KW - Thermotolerance

KW - Trolox

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M3 - Article

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JF - Experimental Gerontology

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ER -

Compounds that confer thermal stress resistance and extended lifespan

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

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