Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems

David W. Graham; Gilles Bergeron; Megan W. Bourassa; James Dickson; Filomena Gomes; Adina Howe; Laura H. Kahn; Paul S. Morley; H. Morgan Scott; Shabbir Simjee; Randall S. Singer; Tara C. Smith; Carina Storrs; Thomas E. Wittum

doi:10.1111/nyas.14036

Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems

David W. Graham, Gilles Bergeron, Megan W. Bourassa, James Dickson, Filomena Gomes, Adina Howe, Laura H. Kahn, Paul S. Morley, H. Morgan Scott, Shabbir Simjee, Randall S. Singer, Tara C. Smith, Carina Storrs, Thomas E. Wittum

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

131 Scopus citations

Abstract

Antimicrobial resistance (AMR) is a significant threat to both human and animal health. The spread of AMR bacteria and genes across systems can occur through a myriad of pathways, both related and unrelated to agriculture, including via wastewater, soils, manure applications, direct exchange between humans and animals, and food exposure. Tracing origins and drivers of AMR bacteria and genes is challenging due to the array of contexts and the complexity of interactions overlapping health practice, microbiology, genetics, applied science and engineering, as well as social and human factors. Critically assessing the diverse and sometimes contradictory AMR literature is a valuable step in identifying tractable mitigation options to stem AMR spread. In this article we review research on the nonfoodborne spread of AMR, with a focus on domesticated animals and the environment and possible exposures to humans. Attention is especially placed on delineating possible sources and causes of AMR bacterial phenotypes, including underpinning the genetics important to human and animal health.

Original language	English (US)
Pages (from-to)	17-30
Number of pages	14
Journal	Annals of the New York Academy of Sciences
Volume	1441
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14036
State	Published - Apr 2019

Bibliographical note

Funding Information:
J.D. received support from the National Pork Board. P.M. received support from JBS Five Rivers Cattle Feeding and Feedlot Health Management Services. T.C.S. received funding to assist in a clinical trial from GOJO related to general hand hygiene. R.S.S. received funding from the Animal Agriculture Alliance, Elanco Animal Health, Zoetis, and Bayer Animal Health. All the other authors declare no competing interests.

Publisher Copyright:
© 2019 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences.

Keywords

animal agriculture
antibiotic use
antimicrobial resistance
fecal matter
soil and wastewater

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/nyas.14036

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Graham, D. W., Bergeron, G., Bourassa, M. W., Dickson, J., Gomes, F., Howe, A., Kahn, L. H., Morley, P. S., Scott, H. M., Simjee, S., Singer, R. S., Smith, T. C., Storrs, C., & Wittum, T. E. (2019). Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems. Annals of the New York Academy of Sciences, 1441(1), 17-30. https://doi.org/10.1111/nyas.14036

Graham, DW, Bergeron, G, Bourassa, MW, Dickson, J, Gomes, F, Howe, A, Kahn, LH, Morley, PS, Scott, HM, Simjee, S, Singer, RS, Smith, TC, Storrs, C & Wittum, TE 2019, 'Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems', Annals of the New York Academy of Sciences, vol. 1441, no. 1, pp. 17-30. https://doi.org/10.1111/nyas.14036

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abstract = "Antimicrobial resistance (AMR) is a significant threat to both human and animal health. The spread of AMR bacteria and genes across systems can occur through a myriad of pathways, both related and unrelated to agriculture, including via wastewater, soils, manure applications, direct exchange between humans and animals, and food exposure. Tracing origins and drivers of AMR bacteria and genes is challenging due to the array of contexts and the complexity of interactions overlapping health practice, microbiology, genetics, applied science and engineering, as well as social and human factors. Critically assessing the diverse and sometimes contradictory AMR literature is a valuable step in identifying tractable mitigation options to stem AMR spread. In this article we review research on the nonfoodborne spread of AMR, with a focus on domesticated animals and the environment and possible exposures to humans. Attention is especially placed on delineating possible sources and causes of AMR bacterial phenotypes, including underpinning the genetics important to human and animal health.",

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AU - Howe, Adina

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Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems

Abstract

Bibliographical note

Keywords

UN SDGs

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