Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack

Gowtham Atluri, Kanchana Padmanabhan, Gang Fang, Michael S Steinbach, Jeffrey R. Petrella, Kelvin O Lim, Angus MacDonald, Nagiza F. Samatova, P. Murali Doraiswamy, Vipin Kumar

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Neuropsychiatric disorders such as schizophrenia, bipolar disorder and Alzheimer's disease are major public health problems. However, despite decades of research, we currently have no validated prognostic or diagnostic tests that can be applied at an individual patient level. Many neuropsychiatric diseases are due to a combination of alterations that occur in a human brain rather than the result of localized lesions. While there is hope that newer imaging technologies such as functional and anatomic connectivity MRI or molecular imaging may offer breakthroughs, the single biomarkers that are discovered using these datasets are limited by their inability to capture the heterogeneity and complexity of most multifactorial brain disorders. Recently, complex biomarkers have been explored to address this limitation using neuroimaging data. In this manuscript we consider the nature of complex biomarkers being investigated in the recent literature and present techniques to find such biomarkers that have been developed in related areas of data mining, statistics, machine learning and bioinformatics.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalNeuroImage: Clinical
Volume3
DOIs
StatePublished - Sep 3 2013

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Neuroimaging
Biomarkers
Molecular Imaging
Data Mining
Brain Diseases
Computational Biology
Bipolar Disorder
Routine Diagnostic Tests
Schizophrenia
Alzheimer Disease
Public Health
Technology
Brain
Research

Cite this

Complex biomarker discovery in neuroimaging data : Finding a needle in a haystack. / Atluri, Gowtham; Padmanabhan, Kanchana; Fang, Gang; Steinbach, Michael S; Petrella, Jeffrey R.; Lim, Kelvin O; MacDonald, Angus; Samatova, Nagiza F.; Doraiswamy, P. Murali; Kumar, Vipin.

In: NeuroImage: Clinical, Vol. 3, 03.09.2013, p. 123-131.

Research output: Contribution to journalReview article

Atluri, Gowtham ; Padmanabhan, Kanchana ; Fang, Gang ; Steinbach, Michael S ; Petrella, Jeffrey R. ; Lim, Kelvin O ; MacDonald, Angus ; Samatova, Nagiza F. ; Doraiswamy, P. Murali ; Kumar, Vipin. / Complex biomarker discovery in neuroimaging data : Finding a needle in a haystack. In: NeuroImage: Clinical. 2013 ; Vol. 3. pp. 123-131.
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