Complete primary structure of human histocompatibility antigen hla-b7: Evolutionary and functional implications

Jack L. Strominger, Victor H. Engelhard, Braydon C. Guild, Thomas G. Kostyk, Doron Lancet, Jose A. Lopez de Castro, Harry T. Orr, Peter Parham, Hidde L. Ploegh, Jordan S. Pober

Research output: Contribution to journalArticle

Abstract

This chapter focuses on the complete primary structure of human histocompatibility antigen— HLA-B7. The histocompatibility antigens and immunoglobulins are both probably the descendants of some common ancestral gene, which may have originally coded for a cell-bound defense molecule. The development of animals with circulatory systems and duplication of that gene resulted later in an evolution in the secretion of the product of some of these genes into the circulation—i.e., the immunoglobulins. The product of the other genes remained membrane bound and probably went on to evolve to become the histocompatibility antigens. The histocompatibility antigens also serve a defense function for the organism. In this case, the cell-bound defense mechanism may serve to protect the organism from invasion by closely related cells, perhaps serving in primitive organisms to maintain colonial identity on the sea floor. At a different level, the organization of information within a genome can be approached via the cloning of major histocompatibility complex genes by recombinant DNA techniques.

Original languageEnglish (US)
Pages (from-to)97-113
Number of pages17
JournalCurrent Topics in Developmental Biology
Volume14
Issue numberC
DOIs
StatePublished - Jan 1 1980

Fingerprint

Histocompatibility Antigens
Genes
Immunoglobulins
HLA-B7 Antigen
Gene Duplication
Recombinant DNA
Cardiovascular System
Major Histocompatibility Complex
Oceans and Seas
Organism Cloning
Genome
Membranes

Cite this

Strominger, J. L., Engelhard, V. H., Guild, B. C., Kostyk, T. G., Lancet, D., Lopez de Castro, J. A., ... Pober, J. S. (1980). Complete primary structure of human histocompatibility antigen hla-b7: Evolutionary and functional implications. Current Topics in Developmental Biology, 14(C), 97-113. https://doi.org/10.1016/S0070-2153(08)60190-8

Complete primary structure of human histocompatibility antigen hla-b7 : Evolutionary and functional implications. / Strominger, Jack L.; Engelhard, Victor H.; Guild, Braydon C.; Kostyk, Thomas G.; Lancet, Doron; Lopez de Castro, Jose A.; Orr, Harry T.; Parham, Peter; Ploegh, Hidde L.; Pober, Jordan S.

In: Current Topics in Developmental Biology, Vol. 14, No. C, 01.01.1980, p. 97-113.

Research output: Contribution to journalArticle

Strominger, JL, Engelhard, VH, Guild, BC, Kostyk, TG, Lancet, D, Lopez de Castro, JA, Orr, HT, Parham, P, Ploegh, HL & Pober, JS 1980, 'Complete primary structure of human histocompatibility antigen hla-b7: Evolutionary and functional implications', Current Topics in Developmental Biology, vol. 14, no. C, pp. 97-113. https://doi.org/10.1016/S0070-2153(08)60190-8
Strominger, Jack L. ; Engelhard, Victor H. ; Guild, Braydon C. ; Kostyk, Thomas G. ; Lancet, Doron ; Lopez de Castro, Jose A. ; Orr, Harry T. ; Parham, Peter ; Ploegh, Hidde L. ; Pober, Jordan S. / Complete primary structure of human histocompatibility antigen hla-b7 : Evolutionary and functional implications. In: Current Topics in Developmental Biology. 1980 ; Vol. 14, No. C. pp. 97-113.
@article{2edb50e0e2394f40b39b29b46c320715,
title = "Complete primary structure of human histocompatibility antigen hla-b7: Evolutionary and functional implications",
abstract = "This chapter focuses on the complete primary structure of human histocompatibility antigen— HLA-B7. The histocompatibility antigens and immunoglobulins are both probably the descendants of some common ancestral gene, which may have originally coded for a cell-bound defense molecule. The development of animals with circulatory systems and duplication of that gene resulted later in an evolution in the secretion of the product of some of these genes into the circulation—i.e., the immunoglobulins. The product of the other genes remained membrane bound and probably went on to evolve to become the histocompatibility antigens. The histocompatibility antigens also serve a defense function for the organism. In this case, the cell-bound defense mechanism may serve to protect the organism from invasion by closely related cells, perhaps serving in primitive organisms to maintain colonial identity on the sea floor. At a different level, the organization of information within a genome can be approached via the cloning of major histocompatibility complex genes by recombinant DNA techniques.",
author = "Strominger, {Jack L.} and Engelhard, {Victor H.} and Guild, {Braydon C.} and Kostyk, {Thomas G.} and Doron Lancet and {Lopez de Castro}, {Jose A.} and Orr, {Harry T.} and Peter Parham and Ploegh, {Hidde L.} and Pober, {Jordan S.}",
year = "1980",
month = "1",
day = "1",
doi = "10.1016/S0070-2153(08)60190-8",
language = "English (US)",
volume = "14",
pages = "97--113",
journal = "Current Topics in Developmental Biology",
issn = "0070-2153",
publisher = "Academic Press Inc.",
number = "C",

}

TY - JOUR

T1 - Complete primary structure of human histocompatibility antigen hla-b7

T2 - Evolutionary and functional implications

AU - Strominger, Jack L.

AU - Engelhard, Victor H.

AU - Guild, Braydon C.

AU - Kostyk, Thomas G.

AU - Lancet, Doron

AU - Lopez de Castro, Jose A.

AU - Orr, Harry T.

AU - Parham, Peter

AU - Ploegh, Hidde L.

AU - Pober, Jordan S.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - This chapter focuses on the complete primary structure of human histocompatibility antigen— HLA-B7. The histocompatibility antigens and immunoglobulins are both probably the descendants of some common ancestral gene, which may have originally coded for a cell-bound defense molecule. The development of animals with circulatory systems and duplication of that gene resulted later in an evolution in the secretion of the product of some of these genes into the circulation—i.e., the immunoglobulins. The product of the other genes remained membrane bound and probably went on to evolve to become the histocompatibility antigens. The histocompatibility antigens also serve a defense function for the organism. In this case, the cell-bound defense mechanism may serve to protect the organism from invasion by closely related cells, perhaps serving in primitive organisms to maintain colonial identity on the sea floor. At a different level, the organization of information within a genome can be approached via the cloning of major histocompatibility complex genes by recombinant DNA techniques.

AB - This chapter focuses on the complete primary structure of human histocompatibility antigen— HLA-B7. The histocompatibility antigens and immunoglobulins are both probably the descendants of some common ancestral gene, which may have originally coded for a cell-bound defense molecule. The development of animals with circulatory systems and duplication of that gene resulted later in an evolution in the secretion of the product of some of these genes into the circulation—i.e., the immunoglobulins. The product of the other genes remained membrane bound and probably went on to evolve to become the histocompatibility antigens. The histocompatibility antigens also serve a defense function for the organism. In this case, the cell-bound defense mechanism may serve to protect the organism from invasion by closely related cells, perhaps serving in primitive organisms to maintain colonial identity on the sea floor. At a different level, the organization of information within a genome can be approached via the cloning of major histocompatibility complex genes by recombinant DNA techniques.

UR - http://www.scopus.com/inward/record.url?scp=0019246059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019246059&partnerID=8YFLogxK

U2 - 10.1016/S0070-2153(08)60190-8

DO - 10.1016/S0070-2153(08)60190-8

M3 - Article

C2 - 7460613

AN - SCOPUS:0019246059

VL - 14

SP - 97

EP - 113

JO - Current Topics in Developmental Biology

JF - Current Topics in Developmental Biology

SN - 0070-2153

IS - C

ER -