Complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome

Dongmei Yang, Zohaib Alam, Xiaohong Cui, Michael Chen, Carly J. Sherrod, Michael A. McVoy, Mark R. Schleiss, Dirk P. Dittmer

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Abstract

The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.

Original languageEnglish (US)
Article numbere00928-14
JournalGenome Announcements
Volume2
Issue number5
DOIs
StatePublished - Jan 1 2014

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