The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.
Bibliographical noteFunding Information:
This work was supported by Public Health Service grant 2RO1HD044864 (to M.R.S.) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, grant 5PO1CA019014 (to D.P.D.) from the National Cancer Institute, and grants 1U19AI107810 (to D.P.D.) and 1RO3AI083919 (to M.A.M.) from the National Institute of Allergy and Infectious Diseases.
© 2014 Yang et al.