Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

William H. Wilson, Declan C. Schroeder, Michael J. Allen, Matthew T.G. Holden, Julian Parkhill, Bart G. Barrell, Carol Churcher, Nancy Hamlin, Karen Mungall, Halina Norbertczak, Michael A. Quail, Claire Price, Ester Rabbinowitsch, Danielle Walker, Marie Craigon, Douglas Roy, Peter Ghazal

Research output: Contribution to journalArticlepeer-review

239 Scopus citations


The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
Issue number5737
StatePublished - Aug 12 2005
Externally publishedYes


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