Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.
|Original language||English (US)|
|Number of pages||8|
|Journal||Dialysis and Transplantation|
|State||Published - Jan 1 1982|