Complement activation by hemodialysis membranes

Y. Kim, A. F. Michael, C. M. Kjellstrand, Michael Mauer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalDialysis and Transplantation
Volume11
Issue number4
StatePublished - Jan 1 1982

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