Complement activation by hemodialysis membranes

Y. Kim; A. F. Michael; C. M. Kjellstrand; Michael Mauer

Complement activation by hemodialysis membranes

Y. Kim, A. F. Michael, C. M. Kjellstrand, Michael Mauer

Pediatrics - Nephrology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.

Original language	English (US)
Pages (from-to)	265-272
Number of pages	8
Journal	Dialysis and Transplantation
Volume	11
Issue number	4
State	Published - Jan 1 1982

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title = "Complement activation by hemodialysis membranes",

abstract = "Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.",

author = "Y. Kim and Michael, {A. F.} and Kjellstrand, {C. M.} and Michael Mauer",

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N2 - Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.

AB - Activation of the complement (C) system by hemodialysis (HD) membranes has been implicated in the transient neutropenia which develops shortly after initiation of HD. There is evidence that this activation causes neutrophils to become sequestered in the microvasculature of the lung, inducing ventilation-perfusion abnormalities and hypoxemia. The purpose of this paper is to describe the changes in serum C components which occur during HD and to define the C pathway activated by HD membranes.

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